abstract：:Current influenza vaccines are primarily targeted to induce immunity to the influenza virus strain-specific hemagglutinin antigen and are not effective in controlling outbreaks of new pandemic viruses. An approach for developing universal vaccines is to present highly conserved antigenic epitopes in an immunogenic con...

journal_title：Expert review of vaccines

authors： Kang SM,Kim MC,Compans RW

更新日期：2012-08-01 00:00:00

abstract：:Streptococcus pneumoniae (pneumococcus) is a major cause of worldwide mortality and morbidity, and to a large extent is vaccine-preventable. Nasopharyngeal carriage of pneumococcus precedes disease and is the source of pneumococcal spread between people. The use of vaccine effect on carriage as part of the vaccine lic...

journal_title：Expert review of vaccines

authors： Simell B,Auranen K,Käyhty H,Goldblatt D,Dagan R,O'Brien KL,Pneumococcal Carriage Group.

更新日期：2012-07-01 00:00:00

abstract：:Protection against acquisition of fully heterologous, neutralization-resistant SIV was achieved in rhesus monkeys with adenovirus/poxvirus vector-based vaccines. Protection against acquisition of infection required the inclusion of envelope antigens and correlated with the induction of binding antibodies against the E...

journal_title：Expert review of vaccines

authors： Esparza J

更新日期：2012-05-01 00:00:00

abstract：:As the Global Polio Eradication Initiative progresses toward the eradication of wild polioviruses, national and global health leaders must still actively consider options for managing poliovirus risks, including risks associated with using oral poliovirus vaccine. Oral poliovirus vaccine continues to represent a highl...

journal_title：Expert review of vaccines

authors： Thompson KM,Tebbens RJ

更新日期：2012-04-01 00:00:00

abstract：:The approval of sipuleucel-T has placed cancer vaccines on the verge of becoming an effective modality. However, there is much to define to understand the intricacies from the multiple confounding factors in vaccine immunotherapy. In this article under review, some patients with metastatic cancer who had limited tumor...

journal_title：Expert review of vaccines

authors： Baxevanis CN

更新日期：2012-03-01 00:00:00

abstract：:Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, remains a major cause of morbidity and mortality worldwide. The presence of chronic respiratory illness is a major risk factor for pneumonia, and smoking (the most common cause of chronic obstructive pulmonary disease) is also an importan...

journal_title：Expert review of vaccines

authors： Vila-Corcoles A,Ochoa-Gondar O

更新日期：2012-02-01 00:00:00

abstract：:Although mass vaccination of the entire population of an endemic area would be the most cost-effective tool to diminish Leishmania burden, an effective vaccine is not yet commercially available. Practically, vaccines have failed to achieve the required level of protection, possibly owing to the lack of an appropriate ...

journal_title：Expert review of vaccines

authors： Doroud D,Rafati S

更新日期：2012-01-01 00:00:00

abstract：:Several new TB vaccines are currently undergoing clinical trials. Among the most promising is a vaccine based upon the modified vaccinia virus Ankara-expressing mycobacterial antigen 85A (MVA85A). Given the widespread use of the current TB vaccine, BCG, many of the new TB vaccines are being tested for their ability to...

journal_title：Expert review of vaccines

authors： McMurray DN

更新日期：2011-12-01 00:00:00

abstract：:Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhanceme...

journal_title：Expert review of vaccines

authors： Borrow R,Dagan R,Zepp F,Hallander H,Poolman J

更新日期：2011-11-01 00:00:00

abstract：:The epidemiology of meningococcal disease in Europe since 1945 has shown fluctuations in incidence, serogroup distribution and case-fatality rate. Outbreaks and epidemics driven by the introduction of new virulent strains into Europe have occurred unpredictably. Epidemics associated with serogroups A and B have occurr...

journal_title：Expert review of vaccines

authors： Kriz P,Wieffer H,Holl K,Rosenlund M,Budhia S,Vyse A

更新日期：2011-10-01 00:00:00

abstract：:Recombinant adenoviruses have emerged as promising viral vectors for CD8(+) T-cell vaccines. Our studies have indicated that unlike most acute infections, the CD8(+) T-cell memory population elicited by recombinant human adenovirus serotype 5 (rHuAd5) displays a dominant effector memory phenotype. Persistent, low-leve...

journal_title：Expert review of vaccines

authors： Bassett JD,Swift SL,Bramson JL

更新日期：2011-09-01 00:00:00

abstract：:Plasmid DNA is a promising vaccine modality that is regularly examined in prime-boost immunization regimens. Recent advances in skin immunity increased our understanding of the sophisticated cutaneous immune network, which revived scientific interest in delivering vaccines to the skin. Intradermal administration of pl...

journal_title：Expert review of vaccines

authors： Elnekave M,Furmanov K,Hovav AH

更新日期：2011-08-01 00:00:00

abstract：:Baculovirus and insect cell culture technologies have mostly been limited to research laboratories for the transient expression of target proteins for drug development purposes. With the renaissance of the vaccine field and the regulatory acceptance of recombinant DNA technology, the baculovirus expression system has ...

journal_title：Expert review of vaccines

authors： Mena JA,Kamen AA

更新日期：2011-07-01 00:00:00

abstract：:The favorable graft-versus-leukemia (GVL) effect that occurs after stem cell transplantation suggests that T cells can eradicate leukemia blasts. T cells specifically recognize peptides and exert an antileukemia effect. Several leukemia-associated antigens (LAAs) have been found to be overexpressed in malignant cells ...

journal_title：Expert review of vaccines

authors： Casalegno-Garduño R,Schmitt A,Schmitt M

更新日期：2011-06-01 00:00:00

abstract：:Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine for...

journal_title：Expert review of vaccines

authors： Regules JA,Cummings JF,Ockenhouse CF

更新日期：2011-05-01 00:00:00

abstract：:The 9th Canadian Immunization Conference was held on 5-8 December 2010 in Quebec City, Canada. Over 1000 academic, public health and vaccine industry scientists, nurses, pharmacists, physicians and policy makers attended the conference, which was organized by the Public Health Agency of Canada-Centre for Immunization ...

journal_title：Expert review of vaccines

authors： Langley JM,Naus M

更新日期：2011-04-01 00:00:00

abstract：:Adjuvants are essential components of most clinically used vaccines. This is because the majority of nonliving vaccines are relatively poor inducers of adaptive immunity unless effective adjuvants are co-administered. Aluminum salts (alum) have been used as adjuvants with great success for almost a century and have be...

journal_title：Expert review of vaccines

authors： Schijns VE,Lavelle EC

更新日期：2011-04-01 00:00:00

abstract：:Efforts to develop a meningococcal vaccine that will include coverage against serogroup B disease have largely focused on outer membrane protein antigens. The protection offered by currently licensed outer membrane vesicle (OMV) vaccines is specific to epidemic strains as their immunodominant antigens are highly varia...

journal_title：Expert review of vaccines

authors： Sanders H,Feavers IM

更新日期：2011-03-01 00:00:00

abstract：:Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...

journal_title：Expert review of vaccines

authors： Croft NP,Purcell AW

更新日期：2011-02-01 00:00:00

abstract：:Bordetella pertussis, responsible for one of the oldest vaccine-preventable diseases in children, has resurged in North America, Europe, Latin America and many countries around the world. Despite new recommended vaccination strategies for adolescents, pregnant women and adults, mortality is still significant in develo...

journal_title：Expert review of vaccines

authors： Ulloa-Gutierrez R,Boza R,Carvajal-Riggioni D,Baltodano A

更新日期：2011-01-01 00:00:00

abstract：:It is generally believed that the role of CD4(+) T cells is to coordinate the different arms of the adaptive immune system to shape an effective response against a pathogen and regulate nonessential or deleterious activities. However, a growing body of evidence suggests that effector CD4(+) T cells can directly displa...

journal_title：Expert review of vaccines

authors： Soghoian DZ,Streeck H

更新日期：2010-12-01 00:00:00

abstract：:Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health. In animal models, cross-protection by vac...

journal_title：Expert review of vaccines

authors： Epstein SL,Price GE

更新日期：2010-11-01 00:00:00

abstract：:Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...

journal_title：Expert review of vaccines

authors： Bai X,Borrow R

更新日期：2010-10-01 00:00:00

abstract：:The production of long-lived, high-affinity antibodies forms the basis of many successful vaccination strategies. Although much is known of the proteins and pathways of the immune system that lead to the production of these antibodies, there are also many processes that remain unexplained or poorly explained. Some vac...

journal_title：Expert review of vaccines

authors： Randall KL

更新日期：2010-09-01 00:00:00

abstract：:In the molecular farming area, transient expression approaches for pharmaceutical proteins production, mainly recombinant monoclonal antibodies and vaccines, were developed almost two decades ago and, to date, these systems basically depend on Agrobacterium-mediated delivery and virus expression machinery. We survey h...

journal_title：Expert review of vaccines

authors： Komarova TV,Baschieri S,Donini M,Marusic C,Benvenuto E,Dorokhov YL

更新日期：2010-08-01 00:00:00

abstract：:Vaccination has been a successful tool in the protection against many infectious diseases, and recent advances in biotechnology have created new techniques and strategies to produce safe and efficacious vaccines for human use. However, developing a protective vaccine against malaria has been a challenge. In this artic...

journal_title：Expert review of vaccines

authors： Coban C,Horii T,Akira S,Ishii KJ

更新日期：2010-07-01 00:00:00

abstract：:Newborns and infants are highly susceptible to infectious diseases, resulting in high mortality and morbidity, particularly in resource-poor settings. Many vaccines require several booster doses, resulting in an extensive vaccine schedule, and yet there is still inadequate protection from some of these diseases. This ...

journal_title：Expert review of vaccines

authors： Flanagan KL,Burl S,Lohman-Payne BL,Plebanski M

更新日期：2010-06-01 00:00:00

abstract：:The WHO has recently recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries. In countries in the Americas, Europe and Australia that have adopted routine childhood immunization against rotavirus, significant reductions in the burden of severe childhood diarrhea have been ...

journal_title：Expert review of vaccines

authors： Tate JE,Patel MM,Steele AD,Gentsch JR,Payne DC,Cortese MM,Nakagomi O,Cunliffe NA,Jiang B,Neuzil KM,de Oliveira LH,Glass RI,Parashar UD

更新日期：2010-04-01 00:00:00

abstract：:The aging process in humans is associated with a decrease in immune function (immunosenescence) and an increase in comorbid disorders. When combined with environmental factors this can lead to an increased risk and severity of infectious diseases. Diseases in older adults (>/=70 years) tend to be more severe and have ...

journal_title：Expert review of vaccines

authors： Maggi S

更新日期：2010-03-01 00:00:00

abstract：:Dr Tamar Ben-Yedidia has more than 15 years of experience in the field of immunology, with specific expertise in the development of vaccines. She started her career with Biotechnology General Ltd (BTG; Rehovot, Israel), working on the development of a recombinant hepatitis B vaccine. She joined the Weizmann Institute ...

journal_title：Expert review of vaccines

authors： Ben-Yedidia T

更新日期：2010-03-01 00:00:00

abstract：:Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the e...

journal_title：Expert review of vaccines

authors： Simmons O,Magee M,Nemunaitis J

更新日期：2010-03-01 00:00:00

abstract：:The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of pu...

journal_title：Expert review of vaccines

authors： Merle CS,Cunha SS,Rodrigues LC

更新日期：2010-02-01 00:00:00

abstract：:Singapore was the location of the 3rd Global Vaccine Congress on 4-6 October 2009, and it provided a suitable place for sharing a range of developments, concepts and challenges associated with vaccines. One of the major goals of this meeting was to present a broad and balanced program of research, development, product...

journal_title：Expert review of vaccines

authors： Kyd JM

更新日期：2010-01-01 00:00:00

abstract：:The 5th International Conference on Vaccines for Enteric Diseases (VED) attracted more than 250 delegates, mainly from industrialized countries. A total of 56 papers were presented and 46 posters were displayed to update recent developments in the field of enteric diseases and vaccine development. This 3-day event ena...

journal_title：Expert review of vaccines

authors： Schaetti C

更新日期：2009-12-01 00:00:00

abstract：:The global burden of disease due to Streptococcus pneumoniae remains high. The licensed 7-valent pneumococcal conjugate vaccine (7vCRM, Prevenar/Prevnar) has successfully reduced invasive disease in the USA, but serotype coverage is incomplete and some evidence suggests that serotype replacement has occurred. Recently...

journal_title：Expert review of vaccines

authors： Prymula R,Schuerman L

更新日期：2009-11-01 00:00:00

abstract：:Francisella tularensis, the causative agent of tularemia, is an organism of concern as a potential biowarfare agent. Progress towards understanding the molecular basis of pathogenicity has been hampered by a lack of tools with which to manipulate the pathogen. However, the availability of genome sequence data for a ra...

journal_title：Expert review of vaccines

authors： Oyston PC,Griffiths R

更新日期：2009-11-01 00:00:00

abstract：:Complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs nake...

journal_title：Expert review of vaccines

authors： Buonaguro FM,Tornesello ML,Buonaguro L

更新日期：2009-10-01 00:00:00

abstract：:Parallel to attenuated and subunit vaccines, DNA vaccines require adjuvant signals in addition to antigen presentation for the induction of adaptive immune responses. As opposed to common beliefs, increasing evidence is showing that Toll-like receptor 9 activation by CpG motifs present in DNA vaccines are not vital fo...

journal_title：Expert review of vaccines

authors： Tang CK,Pietersz GA

更新日期：2009-09-01 00:00:00

abstract：:Optimal vaccine efficacy requires not only a protective antigen, but also a strong immune activator as an adjuvant. Most viral vaccines, such as influenza vaccines and nonviral genetic vaccines (e.g., DNA vaccines), contain nucleic acids, which appear to act as essential 'built-in' adjuvants. Specific receptors, inclu...

journal_title：Expert review of vaccines

authors： Koyama S,Coban C,Aoshi T,Horii T,Akira S,Ishii KJ

更新日期：2009-08-01 00:00:00

abstract：:Combination vaccines have been used for many years in the USA as part of the primary infant immunization series. However, the current program still requires up to 24 injections by 18 months of age. The Advisory Committee on Immunization Practices in the USA recommends the use of combination vaccines whenever possible....

journal_title：Expert review of vaccines

authors： White C,Halperin SA,Scheifele DW

更新日期：2009-07-01 00:00:00